Mission
To provide Life Science Researchers and the Pharmaceutical Industry with analytical tools for investigating metabolic, signaling and secretory function in live tissue.
To provide Life Science Researchers and the Pharmaceutical Industry with analytical tools for investigating metabolic, signaling and secretory function in live tissue.
Problem Facing Biomedical Researchers
General goal in biomedical research: to understand in vivo human physiology. BUT, the ability to do research at early stages of development on humans are obviously limited. Animal models are used, but are expensive, time consuming, low throughput, and importantly, in vivo studies do not allow for detailed study of intracellular mechanisms.
Solution
Live tissue obtained from humans or animals: a balance between emulating in vivo function while allowing for a wide array of detailed measurements. A key utility of the BaroFuse to study tissue function is the flow culture system that provides adequate oxygenation of the tissue to maintain tissue function, while continuously assessing the metabolic and functional state of the tissue.
Investigational Modes
Providing continuous assessment allows the benefits of optimal tissue maintenance by fluidics to be realized by generating quantitative real time data that facilitates
Functional comparison between different tissues, treatment of tissues, human vs animal tissue;
Temporal- and concentration-dependent characterization of mechanistically related parameters;
Identification and study of rapid and slow biochemical regulatory mechanisms.
Functional comparison between different tissues, treatment of tissues, human vs animal tissue;
Temporal- and concentration-dependent characterization of mechanistically related parameters;
Identification and study of rapid and slow biochemical regulatory mechanisms.
